Yes. We have been on several P & O cruises and my husband is a full-time wheelchair user and we take both his powerchair and his manual one (we travel down to Southampton so we can take more equipment etc.) Unless your husband's scooter is a small light one you may have to book a disabled cabin as the doorways in most of the cabins are narrow and you have to put electric wheelchairs/scooters in your cabin so you require more space. We find cruising is a wonderful way to travel as most people are so kind and the crew so helpful. Hope you enjoy the experience.